1 2 - Amino - 3 - ( oxirane - 2 , 3 - dicarboxamido ) - propanoyl - valine an effective peptide antibiotic 1
نویسندگان
چکیده
Institut für Mikrobiologie, Mikrobielle Phytopathologie, Friedrich-Schiller-Universität Jena, D6 07743 Jena, Germany, 1 Leibniz Institute for Natural Product Research and Infection Biology 7 Hans Knöll Institut D-07745 Jena, 2 Institut für Virologie und antivirale Therapie, Friedrich8 Schiller-Universität Jena, D-07743 Jena, 3 Institut für Organische Chemie und Biochemie II, 9 Technische Universität München, D-85747 Garching, 4 Institut für Umweltforschung 10 Technische Universität Dortmund D-44221 Dortmund, 5 Bioorganic Chemistry, Max Planck 11 Institute for Chemical Ecology D-07745 Jena, Germany 6 12 13
منابع مشابه
Assessment of the relevance of the antibiotic 2-amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine from Pantoea agglomerans biological control strains against bacterial plant pathogens
The epiphyte Pantoea agglomerans 48b/90 (Pa48b) is a promising biocontrol strain against economically important bacterial pathogens such as Erwinia amylovora. Strain Pa48b produces the broad-spectrum antibiotic 2-amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine (APV) in a temperature-dependent manner. An APV-negative mutant still suppressed the E. amylovora population and fire blight diseas...
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Stable-isotope-labeled precursors were used to establish the biosynthetic pathway leading from β-alanine towards isoxazolin-5-one glucoside 1 and its 3-nitropropanoate (3-NPA) ester 2 in Chrysomelina larvae. Both structural elements originate from sequestered plant-derived β-alanine or from propanoyl-CoA that is derived from the degradation of some essential amino acids, e.g. valine. β-Alanine ...
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The biochemical and pharmacological properties of a novel non-peptide antagonist of the bradykinin (BK) B(1) receptor, SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3-[[(6-methoxy-2-naphthyl)sulfonyl]amino]propanoyl)amino]-3-(4-[[2R,6S)-2,6-dimethylpiperidinyl]methyl]phenyl)-N-isopropyl-N-methylpropanamide hydrochloride] were evaluated. SSR240612 inhibited the binding of [(3)H]Lys(0)-des-Ar...
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